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The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.

A total knee replacement is usually the result of the cartilage within the joint wearing out due to arthritis. Such surgeries are difficult to perform, require a good deal of rehabilitation, and too often result in sub-optimal outcomes. An implantable shock absorber has now been implanted for the first time in the United States to

Treatment of Partial Rotator Cuff Tear with Ultrasound-guided Platelet-rich Plasma Published online 2017 Aug 14. doi: 10.4103/jcis.JCIS_26_17 Background: The treatment of symptomatic partial rotator cuff tear has presented substantial challenge to orthopaedic surgeons as it can vary from conservative to surgical repair. Researches have established the influence of platelet rich plasma in healing damaged tissue.

Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation. PLoS One. 2016 Jun 16;11(6):e0157048. doi: 10.1371/journal.pone.0157048. eCollection 2016. Russo F1, D’Este M2, Vadalà G1, Cattani C1, Papalia R1, Alini M2, Denaro V1. INTRODUCTION: Osteoarthritis (OA) is the most common musculoskeletal disease. Current treatments for OA are mainly symptomatic and

Possible role of the Ec peptide of IGF‑1Ec in cartilage repair. Armakolas N1, Dimakakos A2, Armakolas A2, Antonopoulos A1, Koutsilieris M2. Mol Med Rep. 2016 Oct;14(4):3066-72. doi: 10.3892/mmr.2016.5627. Epub 2016 Aug 12. The Ec peptide (PEc) of insulin-like growth factor 1 Ec (IGF-1Ec) induces human mesenchymal stem cell (hMSC) mobilization and activates extracellular signal‑regulated kinase 1/2 (ERK 1/2)

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration. Xu Z1, Yin W1, Zhang Y1, Qi X1, Chen Y1, Xie X1, Zhang C1. Sci Rep. 2017 Mar 7;7:43301. doi: 10.1038/srep43301. Platelet-rich plasma (PRP) has gained growing popularity in the treatment of articular cartilage lesions in the last decade. However, the

IGF1Ec expression in MG-63 human osteoblast-like osteosarcoma cells. AIM:Philippou A1, Armakolas A, Panteleakou Z, Pissimissis N, Nezos A, Theos A, Kaparelou M, Armakolas N, Pneumaticos SG, Koutsilieris M. Anticancer Res. 2011 Dec;31(12):4259-65. Abstract AIM: The insulin-like growth factor 1 (IGF1) gene gives rise to multiple transcripts, using an elaborate alternative splicing mechanism. The aim of