The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.
Armakolas N1, Armakolas A2, Antonopoulos A3, Dimakakos A4, Stathaki M5, Koutsilieris M6.
Crit Rev Oncol Hematol. 2016 Dec;108:137-145. doi: 10.1016/j.critrevonc.2016.11.004. Epub 2016 Nov 15.
Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.